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KMID : 0604520070330010001
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Journal of the Society of Cosmetic Scientists of Korea
2007 Volume.33 No. 1 p.1 ~ p.6
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Improved Stability of Liposome by Association of Amphiphilic Polyelectrolytes
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Cho Eun-Chul
Lim Hyung-Jun
Kim Jun-Oh
Chang Ih-Seop
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Abstract
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It has been generally known that liposomes become unstable when they contain cyclodextrins (CDs). Our present studies demonstrate that these liposomes can be stable by association of amphiphilic polyelectrolytes. Transmission electron microscopy and photocorrelation spectroscopy results showed that polymer-associated liposomes containing CDs (() and hydroxypropyl- ()) were more stable than phosphatidylcholine (PC)-cholesterol (Chol) liposomes containing these CDs. We also compared the stability of PC-Chol liposomes with polymer-associated liposomes containing complexed with water-insoluble drug, rhaponticin (Rh). Two liposomes were relatively stable when did not contain Rh, but Rh- complexes triggered the disruption of PC-Chol liposomes. In contrast, polymer-associated Liposomes containing Rh- complexes maintained its stability over 6 months. The skin permeation test demonstrated that drugs solubilized by CDs were delivered better into the skin of guinea pig by using polymer-associated liposomes than by using PC-Chol liposomes. Above results showed that polymer-associated liposomes gave an effective way to stabilize the liposomes containing drug-loaded CDs, which gives an application of liposomes in drug delivery systems.
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KEYWORD
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cyclodextrins, liposomes, vesicles, polyelectrolytes, rhaponticin
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